Comparison on dissolution rates in vitro and pharmacodynamics of Rhizoma Chuanxiong by different forms used as intermediate / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-570433
ABSTRACT
Objective:
To compare the dissolution quantities in vitro of ferulic acid and the analgesic effect of Rhizoma Chuanxiong by supper-micronized powder, fine powder, water extraction, alcohol extraction and double extraction.Methods:
Their dissolution rates in vitro were determined by paddle stirring method, the dissolution quantities of ferulic acid in 60 min were determined by TLC-scaning, the analgesic effects were determined by torsion and hot-plate methods.Results:
The dissolution quantities of ferulic acid were respectively supper-micronized powder (0.645?0.008)mg, fine powder (0.359?0.005)mg, water extraction (0.220?0.004)mg, alcohol extraction (0.526?0.007)mg, double extraction (0.061?0.003)mg. The analgesic effect of supper-micronized powder of Rhizoma Chuanxiong was the best.Conclusion:
The supper-micronized powder of Chuanxiong improved the dissolution quantity of active components and improved the potency.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
Similar
MEDLINE
...
LILACS
LIS