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Determination of Intra-Perfusion cavity Pressure of Isolated Gastrointestinal Canal and Its Application in Pharmacological Experiment / 广州中医药大学学报
Journal of Guangzhou University of Traditional Chinese Medicine ; (6)1999.
Article in Chinese | WPRIM | ID: wpr-570511
ABSTRACT
[Objective] To establish a determination method for isolated gastrointestinal intra-cavity perfusion pressure and to explore its application in pharmacological experiment. [Methods] Determination method for isolated gastrointestinal intra-cavity perfusion pressure was established according to motility of the isolated rat gastric muscle strip and water-sac perfusion manometry and ileum peristalsis of Guinea pigs. Intra-cavity pressure of isolated gastrointestinal canal of rat and guinea pig was observed. [Results] Gastric intra-cavity pressure was markedly increased as added with various doses of acetylcholine (1.25, 2.5, 3.25, 5, 6.25 and 7.5 ?g/mL respectively) in nutrient solution. The ileum intra-cavity pressure was also increased as added with various doses of histamine (0.125, 0.25, and 0.5 ?g/mL respectively) . The effects were in a dose-effect manner and the differences were significant as compared with distilled water group ( P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Guangzhou University of Traditional Chinese Medicine Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Guangzhou University of Traditional Chinese Medicine Year: 1999 Type: Article