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Correlation of HR-HPV infection and p16 gene expression in cervical cancer / 国际检验医学杂志
International Journal of Laboratory Medicine ; (12): 1377-1378,1381, 2014.
Article in Chinese | WPRIM | ID: wpr-570590
ABSTRACT
Objective To detect the expression of p16 and discuss the significance in genesis and development of cervical cancer. Methods FQ-PCR method was used to detect the expression levels of p16 mRNA in cervical cancer(CC),cervical intraepithelial neoplasia(CIN),and normal tissues.And in situ hybridization was used to detect HR-HPV in these tissues.Results The expres-sion levels of p16 were 0.79±0.34,0.70±0.36,0.26±0.21 in CC,CIN and normal cervical tissues,respectively.The difference was significant (P 0.05).The expression level of p16 in HR-HPV positive cases was significantly higher than that in HR-HPV negative cases (P <0.05).Conclusion p16 shows high expression level in cervical cancer,which is closely related to the infection of HR-HPV infection.It suggests that the high ex-pression of p16 play an important role in genesis and development of cervical cancer.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2014 Type: Article