CONNEXIN43 EXPRESSION WITH AGE ADVANCING IN RAT HEART / 解剖学报

ABSTRACT

Objective To investigate the change of Connexin43 expression in rat heart as age advancing. Methods The expressions of Connexin43 in different age of rat heart were determined by immunohistochemistry. Results 1^The expression of Connexin43 was only seen in ventricular myocardium. 2^The Connexin43 immunolabelling of infant rat heart lie much more within the transversely orientated intercalated disk, besides, a fewer have a punclate distribution over the entire surface of the ventricular myocytes, and Connexin43 distributed mainly on the myocyte surface of the parpillary muscles. Connexin43 immunolabelling of young and old rat heart are typically confined to the site of intercalated disk.Conclusion The expressions of Connexin43 are different in different age and different parts of rat heart.