Protective Effect of Complex EGb on Cerebral Ischemic Damage / 中药新药与临床药理

ABSTRACT

Objective: To study the protective effect of Complex EGb(C-EGb) on cerebral ischemic damage. Methods: SD rat model of middle cerebral artery occlusion(MCAO) was established according to the method described by Zea Longa,et al. The neurological symptoms and brain infarction range in rat models were evaluated. Mouse model of cerebral ischemia-reperfusion was set up by ligating bilateral common carotid arteries and loosening them in 30 minutes. Effects of C-Egb on superoxide dismutase (SOD) activity, blood glutathione peroxidase (GSH-Px) level, catalase activity and plasma malonyl dialdehyde (MDA) content were observed. Results: C-EGb markedly improved the neurological symptoms and reduced the range of cerebral infarction in MCAO rats. It also decreased the inhibition of SOD, GSH-Px and CAT activity and reduced the production of MDA in ischemia-reperfusion mice. Conclusion: C-EGb has protective effect on brain tissue from cerebral ischemic damage and its effect is better than that of EGb and that of the mixture of EGb.