Comparison Between Borneol-induced Opening of Blood-brain Barrier and Its Pathological Opening / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-570722
ABSTRACT
Objective:
To observe the difference between borneol-induced opening of blood-brain barrier (BBB) and its pathological opening .Methods:
The expression of inducible nitric oxide synthetase (iNOS) in brain microvascular endothelial cells in normal rats and brain-injury rats before and after treatment of borneol was examined by immunohistochemical methods with S-P staining and iNOS antibody.Results:
iNOS expression was not different in normal rats before and after treatment. However, iNOS expression was increased in brain-injury rats and borneol could inhibit the expression of iNOS.Conclusion:
Borneol-induced opening of BBB is different from pathological opening of BBB. Borneol can increase the pathological opening of BBB and has a protective effect on brain tissue.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
2000
Type:
Article
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