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Effect of Buxu Huayu Prescription on Myeloid Hematopoiesis in Tumor -bea ring Mice After Combined Chemotherapy / 中药新药与临床药理
Article in Zh | WPRIM | ID: wpr-570896
Responsible library: WPRO
ABSTRACT
Objective To observe the effects of Buxu Huayu P rescription(BHP)on myeloid hematopoiesis in tumor -b ear-ing mice after combined chemotherap y.Methods Tumor -bearing mouse models were established by implanting P388tu-mor strain and the arrest of myeloid h ematopoiesis in the models was induced by intraperitoneal injection of c yclophos-phamide(CTX)and cytarabine(Ara -c ).The mice were allocated to 3groups:the normal control group,the model group and BHP group.Peripheral bloo d cell count,bone marrow karyocytes(BMK)count,colony count of progenitors o f granulocytes /monocytes(CCP -GM)and the proliferation of bone marrow cells(BMC)were examined.Results The combination of CTX and Ara -c could decrease plasma hemoglobin(Hb )content,the number of white blood cells(WBC),BMK and CCP -GM and the proliferatio n of BMC in model mice(P
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Full text: 1 Index: WPRIM Language: Zh Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 1993 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 1993 Type: Article