Evaluation of TCM Combined with Western Medicine for Infertility with Ovarian Dysfunction by Detecting Saliva Progestin Level / 广州中医药大学学报

ABSTRACT

[Objective] To search a noninjurious detecting method of progestin level for the evaluation of TCM combined with western medicine for infertility with ovarian dysfunction. [ Methods] Forty - two cases of infertility were treated with clomiphene citrate (CC), human menopausal gonadotropins (HMG) and CC combined with TCM respectively. Progestin levels in saliva and serum of the above cases in luteal phase were detected by radioimmunoassay method and were compared with those in 21 normal women. [Results] Saliva progestin level in luteal phase of the three treatment groups ranged from (294.0?1.5) pg/mL to (499.0 + 75.0) pg/mL, which was similar to that of the normal volunteers. And the matched serum progestin level in luteal phase of the three treatment groups ranged from (28.6 ?4.6) ng/mL to (51.4 ?16.6) ng/mL. After treatment, progestin levels in saliva and serum of pregnant cases in the treatment groups were higher than those of unpregnant, progestin levels in saliva and serum of pregnant cases in the treatment groups were higher than those of unpregnant cases ( P 0.05). [Conclusion] Detecting method of saliva progestin level is practical, effective and convenient and can be used as an alternative of serum progestin level detection. The effect of TCM is similar to that of CC and HMG.