Drug Resistance and Distribution of Pathogenic Bacteria in Lower Respiratory Tract / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study drug resistance and distribution of infectious bacteria in lower respiratory tract among inpatients and outpatients and use the experience for reference of clinical application.METHODS Bacterial culture of the qualified sputum sample of patients who were admitted from Jan to Dec 2005 was done.The bacteria identification and drug sensitivity tests were done by ATB system.RESULTS Totally 687 strains of bacteria were isolated,the dominant were Gram-negative bacilli(81.5%).Among them,the Pseudomonas aeruginosa was 21.3%,the Acinetobacter baumannii was 19.8%,the Klebsiella pneumoniae was 14.3%,the Stenotrophomonas maltophilia was 16.6%,the Escherichia coli was 7.5%,and the others were 17.5%.The second pathogens were fungi(15.9%).The Gram-positive bacteria were the lowest ones.The results of drug sensitivity tests indicated,the imipenem was the most sensitive for Gram-negative bacilli except the P.aeruginosa and the M.stenotrophomonas(99.1% to 100.0%).For the P.aeruginosa,the amikacin was the highest one,and for the S.maltophilia,the highest was sulfamethoxazole-trimethoprim.CONCLUSIONS The dominant pathogenic bacteria in lower respiratory tract in our area are Gram-negative bacteria.For the same antimicrobial agent,different bacteria have a different sensitivity.We should select the antibiotic according to the results of drug sensitivity test.