Low-dose amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting / 中华胸心血管外科杂志

ABSTRACT

Objective: To evaluate the effect, tolerance and safety of low-dose oral amiodarone in the prevention of AF after coronary artery bypass grafting (CABG). Methods: Between 1998 and 1999, 235 adult patients underwent CABG. They were given 0 6 g of amiodarone (80 patients) or placebo (155 patients) daily for 7 days before surgery and 0 2g of amiodarone or placebo daily for 30 days postoperatively. Results: The incidence of postoperative AF was significantly (P=0 001) lower in treatment group (10%) as compared with placebo (21 94%). Only 3 cases had pro-arrhythmic effects and no side effects in treatment group. Conclusion: 1.Perioperative low-dose oral amiodarone significantly reduced the ventricular rate and reduced occurrence and duration of atrial fibrillation after CABG. 2.Low-dose amiodarone is well tolerated and decreased the risks of severe side effects and pro-arrhythmic effects, especially for these patients with high risk factors in perioperative period.