Effect of Bushen Yizhi Prescription on Learning and Memory in Ovariectomized Rats / 中药新药与临床药理

ABSTRACT

Objective To observe the effect of Bushen Yizhi Prescription (BYP) on learning and memory in ovariec-tomized rats. Methods Three - month - old female SD rats were randomized into mimic operation group, model group, BYP group and estrogen control group. Ovariectomy was operated in the three latter groups. After operation, BYP group was treated with gastric infusion of BYP and estrogen group with subcutaneous injection of estrogen. The changes of refer- ence memory and working memory were tested by Morris water maze. Results & Conclusion Sixteen weeks after ovariecto-my, serum estrogen level was markedly decreased, the working memory became poor and the reference memory remained normal. B YP and estrogen can prevent the reduction of working memory in ovariectomized rats.