Effect of Houxiangzhengqi Oral Liquid on the withdrawal syndromes in morphine dependent rats / 中成药

ABSTRACT

Objective: To explore the effects of Houxiangzhengqi Oral Liquid(HOL) on controlling withdrawal syndromes of morphine dependent rats and analgesia of mice. Methods: 60 rats were divided into group A、B、C and D randomly. Group A was injected equivalent 0.9%NaCl(0.2 mL, sc), group B、C and D were injected morphine increasingly(from 20mg?kg -1 to 100mg?kg -1, 5 days, sc) to form patterns of morphine dependent rats. When the 6th day, after group A and B were given 0.9% NaCl(0.5mL?(100g) -1, ig), group C and D were given HOL(100%0.2mL?(100g) -1 and 0.8mL?(100g) -1), respectively, 30 minutes later, by naloxone(4mg?kg -1, ip) withdrawal syndromes. And the withdrawal syndromes was observed and evaluated by the scores and weight lost. Results: The total of scores and their weight loss of group C and D were significantly different from group B(P