The Influence of a Muscle Relaxant on Bispectral Index during the Propofol Induction of Anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 373-377, 2008.
Article
in Korean
| WPRIM
| ID: wpr-57122
ABSTRACT
BACKGROUND:
Although neuromuscular blockade can influence the bispectral index (BIS) during anesthesia, there have been contradictory reports regarding its effects. The purpose of this study was to investigate whether a muscle relaxant affected the level of BIS during propofol anesthesia.METHODS:
Forty-eight healthy patients undergoing elective surgery under general anesthesia were enrolled in this prospective, randomized, double-blind study. All patients received an effect-site targeted concentration of propofol via a TCI system that was titrated until loss of consciousness occurred. The patients then received either an injection of vecuronium (relaxant group, n = 24) or normal saline as a placebo (placebo group, n = 24) at 3 minutes after loss of consciousness. The BIS and electromyogram (EMG) activity were recorded from anesthetic induction to 4 minutes after injection of the vecuronium or placebo.RESULTS:
The BIS significantly decreased after injection in both groups (P < 0.05), however, the decrease in the BIS was larger in the relaxant group than in the placebo group (P < 0.05). The decrease of EMG activity was not significantly different between the two groups after administration of vecuronium or placebo.CONCLUSIONS:
During propofol induction of anesthesia, a muscle relaxant decreased BIS significantly without decreasing the EMG activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Unconsciousness
/
Vecuronium Bromide
/
Propofol
/
Double-Blind Method
/
Prospective Studies
/
Neuromuscular Blockade
/
Anesthesia
/
Anesthesia, General
/
Muscles
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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