Experimental study of the effect of Angelica polysaccharide on proliferation and differentiation of human CFU-GM and HL-60 cells / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-571236
ABSTRACT
Objective:
To study modern biological mechanism for hematonic and antitumor of Angelica Sinensis (oliv) Diels.Methods:
By using the techniques of hematopoietic cells culture in vitro,morphological observation,flow cytometry and immunocytochemistry,the effect of Angelica polysaccharide (APS) on proliferation and differentiation of human CFU-GM and promyelocytic leukemia cell line (HL-60) was studied.Results:
APS could markedly promote the colony formation of CFU-GM and could significantly inhibit the proliferation of HL-60 in vitro.The inhibitory effect is concerned with the concentration of APS.APS may prevent HL-60 from the Go phase entering the S/G2+M phase,thus prohibit the synthesis of DNA.APS may also promote HL-60 entering the process of apoptosis.Conclusion:
APS may not only promote normal hematopoiesis,but also inhibit the proliferation of leukemia cell and it can be a natural inducer for therapy of malignant tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1986
Type:
Article
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