A study on collagen constitute and formation of hypertrophic scar in different age periods / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-571369
ABSTRACT
Objective:
To investigate the mechanism of hypertrophic scar formation in different age periods.Methods:
The expression of type I and type Ⅲ collagen of hypertrophic scar in different age periods was measured with immunohistochemistry which was divided into two groups 1~19 years old and 20~50 years old,and the same measure was adopted in normal skin divided into four groups-fetal,1~19,20~50,and more than 60 years old .The quantities of type I and type Ⅲ collagen and the ratios were analyzed.Results:
①The ratio of type Ⅰ/type Ⅲcollagen of normal skin had a guadually increasing tendency.②The ratio of type Ⅰ/type Ⅲ collagen of HTS was increasing compared with normal skin(NS),and relative quantities of type I collagen of HTS was significantly increasing.The ratio of type Ⅰ/type Ⅲcollagen of HTS in group of 1~19 year old was highter than that in the group of 20~50 year old .Conclusion:
Normal structure of the skin is decided by quantities and ratio of type I and type Ⅲ collagen.The formation of hypertrophic scar in different age periods relates to maladjustment of the ratio of type I and type Ⅲ collagen.Collagen synthesis and regulation of its constitute are finished after about six months.They keep relatively stable within 6 month to 2~3 years.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1986
Type:
Article
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