The influence of MDR1 gene therapy on the survival rate of few late hepatocarcinoma balb/c mouse / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-571555
ABSTRACT
Objective:
The study was to improve the protection of the bone marrow during the chemotherapy of late hepatocarcinoma balb/c mice and increase its survival rate.Methods:
Cultivated H22 hepatocarcinoma cell was injected into the balb/c mouse to make the animal model. MDR1 gene was transferred into the hematopoietic cells of murine bone marrow by the mediation of retrovirus vecter and transplanted into the balb/c mouse with hepatocarcinoma exposure with 60 Co-? ray in advance.WBC were investigated 3 days after high-dose chemotherapy. The function and the expression of MDR1 gene were detected by PCR method and IC method in vitro and in vivo.Results:
WBC of the different dose experiment group was higher than that of the control group obviously ( P 0.05) ,but in the second week WBC counting of the 0.8mg/kg group was lower than that of the other two groups( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2003
Type:
Article
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