The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the safety of high intensity focused ultrasound(HIFU) for the treatment of implanted rabbit breast tumor.Methods:Forty New England rabbits were randomly divided into the following groupsHIFU treatment group(20),surgery group(10) and control group(10).HIFU ablation was performed at focal peak intensity 11500W/cm with a frequency of 1.6MHz in HIFU group.In surgery group all animals underwent lumpectomy.The animals in control group underwent pseudo-irradiation.The sonograms of target tumor were assessed before and immediately after HIFU ablation.The treated tumor was removed immediately after HIFU,and the lesion was measured by gross examination.Routine serum chemistry examination including hepatic,renal function tests,and serum electrolytes in all animals were performed before and at 1st,3rd,5th and 7th days after treatment.Also tumor metastases were observed after treatment.Results:The gray-scale of target tumors on ultrasound image was low before HIFU and increased immediately after HIFU irradiation.The hyperechoic location was the same as the lesion observed by gross observation.The necrotic lesion completely covered the tumor.No significant differences were observed in hepatic,renal function tests,and serum electrolytes before and after therapy in HIFU group.And these indices were not significantly different in HIFU treatment group,surgery group and control group,respectively.The metastatic rates of HIFU treatment group and surgery group were 20% and 30% respectively.They were significantly different from that of control group(100%,P