Instruction on breast-feeding with hepatitis B virus markers positive mothers / 重庆医科大学学报

ABSTRACT

Objective:To provide a correlation evidence in laboratory for instruction breast-feeding,the investigation of positive rates with serum hepatitis B virus markers(HBVM) in parturients and their infants of breast-feeding to HBVM antigen positive mothers.Methods:The serum HBVM of pregnant women and their infants(12～18th month)were determined by ELISA and HBV-DNA in positive serum and colostrum were determined by fluorescence quantitative PCR,and whole process of immune-protection for pregnant women and their infants.The relation between HBVM in the infant serum and the feeding way was analysed.Results:In 67 case parturient of serum HBVM antigen positive,the positive rate of HBV-DNA was 84%,26% in serum and colostrum with HBeAg positive and HBeAg negative mothers;and there was a positive relationship between the serum and colostrum.The positive rate of HBeAg of serum mothers were 41% and 13% in the artificial feeding group and breast feeding group,there was significant difference between them( P 0.05).Conclusion:As determinations of HBV-DNA were negative in colostrum,the breast-feeding was safe to HBVM antigen positive mothers by active and passive immunization with pregnant women and their infants.