The study of the activities of antithrombin Ⅲ in several thrombophilia / 重庆医科大学学报

ABSTRACT

Objective:To investigate thc changes and clinical significance of antithrombin Ⅲin pregnancy induced hyperternsion(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE) and acute non-lymphoid cell leukemia(ANLL).Methods:AT-ⅢA was measured by chromogonic substratc method in pregnancy induced hypertension(PIH),diabetes mellitus(DM),nephritic syndrome(NS),systemic lupus erythematosus(SLE),acute non-lymphoid cell leukemia(ANLL) and control group.Results:AT-ⅢA in women with PIH and normal prcgnancy and the DM with conplication and the NS and the SLE and the ANLL was significantly lower than that in the control.No significant difference in AT-ⅢA was found between the DM without complication and the control.Conclusion:Determination of AT-ⅢA has great value in the diagnosis of thrombophilia.