Effects of ciprofloxacin on the heart and brain electrical power spectra of rats / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the effects of ciprofloxacin on the heart and brain electrical power spectra of rats.Methods:Male wistar rats received ciprofloxacin 100mg/kg through their jugular vein.The heart and brain electrical power spectra of rats were recorded before administration as contrast,and at 10,20,30,60,120 minutes after administration as experiments respectively.RR 512 soft ware was used to analyze heart electrical RR variance and low frequency power and high frequency power,and Coherence software was employed to study brain electrical ?,?,?,? power.Results:At 10 - 6 0minafter do sage ,heartelectrical RRvariance was distinct lylarger,and low frequencypower was evidentlylower,and highfrequencypower was signi ficantly higher than those determined be foreadministration .SpikewavesfrequentlyappearedintheECOGofratsat 13minto 6 0minafteradministration .At 10minafter dosage,thebrainelectricaltotalpowerand?powerweredistinctlylowerthanthosebeforeadministration .At 12 0min ,?,? ,?wave powerwereobviouslyhigher,and?/?and?/(? +? +?)valuewereevidentlylowerthanthosebeforeadministration ,buttheywere notchangedatothertimes.Conclusion:The excitability of sympathe ticnerv eof the heartwas weakened and the irritability of pneu mogastricnerve was enhanced ,and the hear tratevariabi lity in creases,and the excitability of centralnerve was induced by cipr of loxacin .