THE REGULATION OF EXOGENOUS ESTRADIOL IN TRANSCRIPTIONALACTIVITY OF REGENERATING HEPATOCYTES IN RATS / 解剖学报
Acta Anatomica Sinica
;
(6)1957.
Article
in Chinese
| WPRIM
| ID: wpr-572418
ABSTRACT
Objective To research the effect of exogenous estradiol(E-2) on transcriptional activity of regenerating hepatocytes in rats. Methods The E-2 levels in serum were measured using RIA and the numbers of argyrophil nucleolar organizer regions(AgNORs) were investigated. Results Rat serum E-2 level gradually declined after ovariectomy,and no E-2 could be measured after the 15th day.Exogenous E-2 could promote transcriptional activity of regenerating rat hepatocytes,particularly during the first 24h after PH,there was a dose-dependent increase in numbers of AgNORs 24-36h after PH,the exogenous E-2 cause a dose-dependent decrease in numbers of AgNORs,but all of the values were higher than that of control group.Conclusion E-2 can regulate the transcriptional activity of regenerating hepatocytes in rats.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Anatomica Sinica
Year:
1957
Type:
Article
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