Influence of Gusongbao Capsule on the Bone Morphological and Blood Biochemical Indexes in Rats with Osteoporosis Induced by Vitamin A Acid / 中药新药与临床药理
Article
in Zh
| WPRIM
| ID: wpr-572492
Responsible library:
WPRO
ABSTRACT
Objective To observe the anti-osteoporosis effect of Gusongbao capsule (GC).Methods Osteoporosis rat models were induced by gastric infusion of vitamin A acid at a dose of 70 mg/kg for 14 days. The bone morphological and blood biochemical indexes and the amount of calcium and phosphorus in urine excreted every day were determined in both treatment group (treated with Gusongbao) and model control group.Results In the treatment group,the average width of bone trabecula,relative bone volume,average thickness of bone cortex,bone calcium,cell number in per unit area of bone trabecula,and the average gray degree of caput femoris and femoral shaft were higher than those in the moderate group. High dose (0.8 g/kg) and middle dose (0.4 g/kg) of GC increased bone phosphorus level and decreased urine calcium level markedly and high dose of GC also increased serum level of CT (P
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Index:
WPRIM
Language:
Zh
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
1993
Type:
Article