Interleukin-4 Receptor Expression on Human Renal Cell Carcinoma Cell Lines by a Reverse Transcription-Polymerase Chain Reaction / 대한비뇨기과학회지
Korean Journal of Urology
;
: 121-127, 1995.
Article
in Korean
| WPRIM
| ID: wpr-57253
ABSTRACT
Recently interleukin-4 (IL-4) has been suggested to be a promising therapeutic agent for the malignant tumors of both murine and human origin. The effect of IL-4 is mediated by IL-4 receptor (IL-4R), which has been shown to be expressed in many normal and tumor cell lines. We herein tested two cell lines of human renal cell carcinoma (RCC), Caki-1 and CURC-II, for the expression of IL-1R gene. On the reverse transcription-polymerase chain reaction study, both cell lines expressed IL-4R mRNA. The present study suggests that it would be worthwhile to investigate the anti-tumor effect of IL-4 on Caki-l and CIJRC-II, which may help to develop new therapeutic strategies for RCC using IL-4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Carcinoma, Renal Cell
/
Gene Expression
/
Cell Line
/
Interleukin-4
/
Receptors, Interleukin-4
/
Cell Line, Tumor
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1995
Type:
Article
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