The effect of arsenic trioxide(As_2O_3) on mitochondria of hepatic Vx-2 carcinoma in rabbits by transcatheter arterial infusion / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the action of arsenic trioxide(As 2O 3)on mitochondria of hepatic Vx-2 carcinoma by transcatheter arterial infusion(TAI).Methods:Fifty New Zealand rabbits weighing 2-3kg with hepatic Vx-2 carcinoma were randomly divided into five groups evenly.Two weeks after the tumor was implanted,the rabbits were treated with As 2O 3 (experimental groups),cisplatin or normal saline(control groups)by TAI for 7 days consecutively.Three weeks after drug administration,the mitochondrial morphological changes and mitochondrial specific surface areas of the tumor and hepatic tissues were investigated under transmission elcetron microscope,at the same time apoptosis of the tumor was observed.Results:The mitochondrial morphological changes of tumor were obvious in the experimential groups as compared with control groups( P