Relationship of hypoxia-inducible factor-1 ? expression and vascular endothelial growth factor in SKOV-3 ovarian cancer model / 中华妇产科杂志
Chinese Journal of Obstetrics and Gynecology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-572823
ABSTRACT
Objective To investigate the correlation of hypoxia-inducible factor (HIF)-1? and va scular endothelial growth factor (VEGF) or micro-vessel density ( MVD). Methods The ovarian cancer cell line SKOV3 was transplanted into nude mice to form xenog eneic tumor. Mice were treated with rapamycin 4mg/kg,sulindac 100 mg/(kg.d) a nd saline 200 ?l respectively. Expression of HIF-1? and VEGF proteins and MV D were determined by immunohistochemistry. The mRNA of Glut1 and VEGF was studi ed by RT-PCR. Results The positive expression of HIF-1? and VEGF was moderate to strong, and MVD was high (31?8) in control group. In rapamycin treated group, the expression of H IF-1? was inhibited to weak positive or negative (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Obstetrics and Gynecology
Year:
2000
Type:
Article
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