Effect of radiotherapy on P-glycoprotein expressionin nasopharyngeal squamous carcinoma / 重庆医科大学学报

ABSTRACT

Objective:To investigate preliminarily the expression of P-glycoprotein(pGp),a multi-drug resistance gene-1 product,in patients with nasopharyngeal squamous carcinoma(NPSC) before and after radiotherapy.Methods:pGp was detected by immunohistochemistry with one monoclonal antibody JSB-1 before and after radiotherapy in fourty-eight patients with NPSC.None of them had received neoadjuvant chemotherapy or radiotherapy.Results:The positive rate of pGp expression in the patients with NPSC before radiotherapy was 18.75%(9/48).But the positive expression rate of pGp after radiotherapy was 75.00%(36/48).pGp expression rate after radiotherapy was significantly higher than that before radiotherapy( P