Effect of TSPG on apoptosis of K562 cells and the expression of Fas,sfas / 重庆医科大学学报

ABSTRACT

Objective:Our purpose is to clarify the mechanisms for total saponins of Panax ginseng(TSPG) inducing K562 cells to apoptosis.Methods:By using morphological observation and TUNEL,the effect of TSPG on apoptosis of K562 cells were studied.The expression of Fas was studied by immunocytochemistry,and sfas was assayed by ELISA.Results:The results indicated that 50,100?g/ml TSPG could induce K562 cells to apoptosis.Our experiment also showed after induced by TSPG,the ratio of positive K562 cells of expression Fas is increased ( P