An effect comparison of perioperative intravenous Metoprolol bolus in 87 cases and intravenous calcium iron antagonist injection in 48 cases with noncardiac Surgery / 介入放射学杂志

ABSTRACT

Objection To compare the efficacy and tolerance of perioperative intravenous Metoprolol or calcium iron antagonist injection on patients with cardiac complications which undergoing noncardiac surgery. Method The clinical data of 135 patients who underwent noncardiac surgery from March 2003 to May 2004 was analyzed. According to the different drugs used to treat the perioperative cardiac complications (tachycardia arrhythmia, hypertension and myocardium ischemia), patients were allocated to metoprolol group (87 cases) and calcium antagonist group (48 cases, including Verapamil 21 patients and Diltiazem 27 patients). The effects of the therapy on heart rate and blood ressure control and ischemia relieving were compared between two groups. Results There is no significant difference at baseline data between two groups. Compared with calcium antagonist, intravenous metoprolol could more reduce heart and relieve myocardium ischemia quickly. The effect of blood pressure controlling was more significant in calcium antagonist group than in metoprolol group. The incidence of side-effects events was lower in metoprolol ( 8.0%) than in calcium antagonist group (22.9%).Conclusions Intravenous metoprolol injection is effective and safe in treating perioperative cardiac complications in patients with noncardias surgery.