Intraarterial chemotherapy for bulky uterine cervical carcinoma / 介入放射学杂志

ABSTRACT

Objective To evaluate the effects of intraarterial chemotherapy for bulky uterine cervical carcinoma. Methods One hundred untreated patients with stage Ⅰb-Ⅲa uterine cervical carcinoma were included in the study. Intraarterial chemotherapy was undertaken with a combination of Cisplatin (DDP) 50 mg/m 2 or Paraplatin 300 mg/m 2, Epiadriamycin (E-ADM)45 mg/m 2 one time/2ws. Results The overall response rate was 87.0%. Radical hysterectomy was performed in 73 patients with less bleeding and shorter operative time than those of untreated group. The major adversary effects were leukocytopenia, nausea, and vomiting. Conclusions Intraarterial chemotherapy is effective for preoperative treatment of uterive cesrvical cances with easier radical hysterectomy, especially for inoperable bulky ones.