The expression of P53,K-ras and hMSH2 in ulcerative colitis-associated colorectal cancer / 中华消化杂志

ABSTRACT

0.05). The positive rate of MSI in UC with dysplasia was significantly higher than that in UC (P0.05). The loss of hMSH2 protein expression was not found in UC with dysplasia and UCACRC. Conclusions Both the mutations of P53, K-ras genes and MSI are early events in UCACRC. There is no relationship between MSI and loss of hMSH2 protein expression in (UCACRC).