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The role of mitochondrial DNA mutation on neurodegenerative diseases
Experimental & Molecular Medicine ; : e150-2015.
Article in English | WPRIM | ID: wpr-57310
ABSTRACT
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA, Mitochondrial / Reactive Oxygen Species / Neurodegenerative Diseases / Molecular Targeted Therapy / Mitochondria / Mutation Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA, Mitochondrial / Reactive Oxygen Species / Neurodegenerative Diseases / Molecular Targeted Therapy / Mitochondria / Mutation Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2015 Type: Article