The role of mitochondrial DNA mutation on neurodegenerative diseases
Experimental & Molecular Medicine
;
: e150-2015.
Article
in English
| WPRIM
| ID: wpr-57310
ABSTRACT
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Mitochondrial
/
Reactive Oxygen Species
/
Neurodegenerative Diseases
/
Molecular Targeted Therapy
/
Mitochondria
/
Mutation
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2015
Type:
Article
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