The effects of topiramate and valproate sodium on spontaneous motor activity behavior and isolation-induced aggression in mice / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1987.
Article
in Chinese
| WPRIM
| ID: wpr-573214
ABSTRACT
Objective:
To study the effects of valproate sodium and topiramate on spontaneous motor activity behavior and isolation-induced aggression in mice,and thus to provide evidence for drug treatment.Methods:
Male Kunming mice were isolated for 40~45days as an animal model of isolation-induced aggression.The isolated and group-housed mice were administrated with different doses of valproate sodium (0mg/kg、50mg/kg、100mg/kg、200mg/kg) and topiramate(0mg/kg、25mg/kg、50mg/kg、100mg/kg).The aggressiveness of isolated mice was measured 30min after the administration of valproate sodium or 120min after the administration of topiramate.Results:
Valproate sodium and topiramate could dose-dependently prolong the latencies to attacking.They could also decrease spontaneous motor activity.Conclusion:
Both valproate sodium and topiramate are inhibitors of aggression behavior in isolated mice.Topiramate and valproate sodium have synergism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1987
Type:
Article
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