Dosage and real time monitoring using two-dimensional ultrasound in extracorporeal damaging rabbit liver with high intensity focused ultrasound / 重庆医科大学学报

ABSTRACT

Objective:To investigate the dosage in damaging rabbit liver with high intensity focused ultrasound (HIFU) and the feasibility of real time monitoring with two-dimensional ultrasound.Methods:With fixed HIFU emission power,working frequency,radiation depth,40 rabbit livers were damaged extracorporeally with a HIFU mode of intermittent fixed-spot irradiation.Echo of target region was measured and its changes with time were observed,the extent of echo enhancing region were also measured.Coagulative necrosis in rabbit livers were measured after dissection and pathological inspection were made.Results:Irradiation of extracorporeal HIFU made a coagulative necrosis region in rabbit liver,energy efficiency factor (EEF) were 9.22?1.57 J/mm 3,elevating echo of target region were observed,necrotic volume and maximum scar of rabbit livers were related linearly with volume and maximum area of elevating echo region measured by two-dimensional ultrasound.Conclusion:For specific tissue,there are a great deal experiments to do to decide a common HIFU dosage,two-dimensional ultrasound can realize real time monitoring of target region necrosis,echoic change in target region can predict coagulative necrotic volume.