Effect of Xiaoyao Powder on Ca~(2+) in Hippocampal Synaptosome of Multi - Stress Model Rats / 广州中医药大学学报

ABSTRACT

[Objective] To observe the influence of Xiaoyao Powder on the concentration of Ca2+ in hippocampal synaptosome of multi - stress model rats.[Methods] Wistar rats were randomly allocated to five groups normal control (Group A) , model 1 (Group B), Xiaoyao Powder 1 (Group C), model 2 (Group D), and Xiaoyao Powder 2 (Group E) . All the rats except those of Group A were replicated to chronic multi-stress models. At the meantime, Groups C andE were given the decoction of Xiaoyao Powder, 1.06g each for 21 days and 42 days respectively. Groups A, B and D were administered by gavage the equal amount of normal saline. After the administration, the hippocampal homogenate was taken to detect the concentration of hippocampal synaptic Ca2+ by fluorimetry. [Results] Compared with Group A, the concentration of Ca2+ in hippocampal synaptosome of Groups B and C was increased, having significant difference ( P