Comparison of Efficacy of Transcatheter Closure of Atrial Septal Defect with Amplatzer Septal Occluder between Children and Adult

ABSTRACT

PURPOSE: This study sought to analyze the safety, efficacy, and follow-up results of percutaneous closure with Amplatzer septal occulder (ASO) for secundum atrial septal defect (ASD) in less than 10 years old by comparing to those of adult. METHODS: We divided 49 enrolled subjects to two groups as childhood group (25 patients, 10 years). We evaluated hemodynamic changes, including Qp/Qs, systolic right ventricular pressure, pulmonary artery pressure in pre- and post-treatment. The residual shunt rate and complications were investigated. Then, we compared the results between two groups. RESULTS: The success rate of two groups was not statistically different (100% vs 95.8%). The hemodynamic changes, including Qp/Qs, systolic right ventricular pressure, pulmonary artery pressure were statistically significant between pre- and post-treatment (all P0.2). The residual shunt rate and complications occurrence rate were not statistically significant between two groups. CONCLUSION: The cure rate and complications by percutaneous closure of ASD with ASO were not different between in children and in adult. This procedure was an effective treatment modality for ASD in children like in adult.