Leukocyte depletion filtration on systemic inflammatory response in patients undergoing valve surgery / 中华胸心血管外科杂志

ABSTRACT

Objective To evaluate the effects of leucocyte-depleting filtration on systemic inflammatory response in patients undergoing valve surgery. Methods Fifty-two patients underwent elective mitral valve or mitral and aortic valves replacement surgery in this study. Patients were randomly divided into two groups. Each group (n=26) was placed on the same cardiopulmonary bypass (CPB) circuit except for the arterial line filter. One group of patients (CG) used the TERUMO ordinary arterial line filter as a control, and the Pall LG-6 leucocyte-depleting arterial line filter and TERUMO ordinary arterial line filter were incorporated into the arterial line of extracorporeal circuit in a parallel way in the EG. The leukocyte-depleting filters were used from 5-10 minutes before aortic cross clamp release to the end of CPB. Intra- and postoperative variables consist of leucocyte counts, serum levels of cytokines and complement C_3, body temperature and the usage of antibiotics. Statistical analysis with indepent-samples t-tests, paired-samples t-test, correlate and chi-square (SPSS11.5) was performed on all data to test for significant differences. A P value of