Relationship between VacA genotypes of Helicobacter pylori and gastric diseases / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-573549
ABSTRACT
Objective:
To investigate the distribution of Helicobacter pylori (H.pylori) VacA genotypes in different gastrointestinal diseases and the relationship among each other.Methods:
VacA genotypes of 108 H.pylori strains isolated from patients with chronic gastritis,peptic ulcer and gastric cancer were tested by polymerase chain reaction (PCR).Results:
The frequencies of the signal allele sla,slb and the middle-region allele m1,m2 were 85 (79%),22 (20%),29 (27%),77 (71%) respectively.The numbers of H.pylori strains of VacA s1a/m2 positive were 66 (61.1%).The s2 form was not found.The positive rates of VacA s la of H.pylori strains isolated from patients with chronic gastritis,peptic ulcer and gastric cancer were 65.4% (34/52),90% (36/40) and 94% (15/16) respectively.Conclusion:
The majority of H.pylori strains isolated from Chongqing patients express s1a/m2.The s1a/m2 genotype is dispersed in all of the gastrointestinal diseases associated with H.pylori.However the s2 form is not found.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
1986
Type:
Article
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