Protective effect of shenfu preconditioning on myocardium against ischemia-reperfusion injury in rats / 重庆医科大学学报

ABSTRACT

Objective:To study the relationship between the protective effect of shenfu parenteral solution (SF) on myocardium in rats and HSP 70 .Methods:To establish general ischemia reperfusion(I/R) model.Thirty-five healthy white rats were divided into five groups randomlysham operation group(group C),I/R30 group (including 2 groups),SF group(including 2 groups).After myocardial ischemia lasting for 40min,then reperfusing for 30min or 120min.To detect hemodynamic parameter,myocardium MDA content,SOD activity,HSP 70 expression and ultrastructure were examined.Results:Compare with I/R groupLVSP and ?dp/d/max rose up,however,LVEDP decreased( P