Effects of tetrandrine on fibroblast's proliferation derived from hypertrophic scar / 重庆医科大学学报

ABSTRACT

Objective:To probe into the effects of tetrandrine on fibroblast proliferation derived from hypertrophic scars and evaluate the role of tetrandrine in the treatment of scars.Methods:Taking the cultured fibroblasts derived from human hypertrophic scars as model,the effects of tetrandrine on fibroblast proliferation and content of extracellular collagen were observed and analyzed by MTT reduction assay,flow cytometry after propidium iodide staining and modified chloraseptine T oxidizing assay.Besides,their relationship was analyzed by linear correlation.Results:Growth curve descent,TD prolonging and extracellular collagen reduction in a dosage and time dependent manner were observed.Moreover,they changed in positive correlation with each other.Conclusion:Tetrandrine can inhibit fibroblast biological action derived from hypertrophic scars,which is one of the mechanism of anti-scarring action of tetrandrine.