A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma
Annals of Dermatology
; : 91-96, 2006.
Article
in En
| WPRIM
| ID: wpr-57360
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ABSTRACT
We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pneumonia
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Skin
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World Health Organization
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B-Lymphocytes
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Lymphocytes
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Cheek
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Lymphoma, B-Cell
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Cisplatin
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Classification
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Dermis
Limits:
Aged
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Humans
Language:
En
Journal:
Annals of Dermatology
Year:
2006
Type:
Article