Effect of Auricularia auriculajudae polysaccharide on cell immunity of tumor-bearing mice / 中成药

ABSTRACT

AIM: To study the influence of Auricularia auriculajudae polysaccharide (APP) on celular immunity of mice bearing tumor. METHODS: Influence of AAP on lymphocyte proliferaton and IL-2 production of H_(22) mice and was observed by cell cultivation. And the influence of AAP on free Ca~(2+) concentration in lymphocytes of H_(22) mice through laser sacanning confocal microscope (LSCM). RESULTS: AAP can lengthen the average survival time of H_(22) tumor-bearing mice. The research of immune function indicated that AAP can improve the tumor-bearing mice's celular immunity the increase in lymphocytes, and the product of IL-2 and Ca~(2+) concentration inside lymphocytes. CONCLUSION:AAP has a function of anti-tumor. The mechanism has a relation to raising the celular immunity.