Effects of Cistanchis Glycosides on Learning and Memory Impairment in Mice / 中药新药与临床药理

ABSTRACT

Objective To observe the effects of cistanchis glycosides on scopolamine -induced impariment of learning and memory and on sodium nitrite -induced impariment of learning and memo ry consolidation in mice.Methods Step down test was performed to reflect th e learning and memory of mice.Cistan chis glycosides were administered c onsecutive-ly for 30days.The mice were trained o n the 29th day and measurements were c arried out on the 30th day .Latent period and number of errors within 5min were noted.Scopolamine was given by intr aperitoneal injection 15min before train-ing,and sodium nitrite was administered subcutaneously right after trainin g.Results(1)Compared with model mice in-duced by scopolamine,cistanchis glycosides 200and 400mg /kg together with piracetam 600mg /k g considerably in-creased latent period and decreased error times.Cistanchis glycosides100mg /kg also increased latent time but decreased error times to some extent.(2)Compared with model mice induced by s odium nitrite,cistanchis glycosides 200and 400mg /kg increased latent time significantly but had no significant effect on the error times.Cistanchis glycosides 100mg /kg decreased latent time and error time s to some extent.Conclusion Cistanchis glycosides could obviou sly improve scopo-lamine -induced impariment of learn ing and memory and on sodium nitrite -induced impariment of learning and memory in mice.