THE CHANGES OF ENDOTHELIN-A RECEPTOR mRNA IN THE CEREBRAL BASILAR ARTERY OF RATS WITH SUBARACHNOID HEMORRHAGE / 解剖学报

ABSTRACT

Objective To detect the changes of Endothelin-A receptor mRNA in the cerebral basilar artery of rats with experimental subarachnoid hemorrhage-induced cerebral vessel spasm as well as its effect. Methods Fifty-six Wistar rats were randomly divided into normal, experimental,sham-operated and saline-control groups. The experimental group was subdivided into subarachnoid hemorrhage(SAH)2,3,7 and 14?d groups. Reverse transcription polymerse chain reaction was used to study the changes of Endothelin-A receptor mRNA level in the cerebral basilar artery of rats with experimental subarachnoid hemorrhage-induced cerebral vessel. Results ET-A receptor mRNA level of basilar artery in SAH2, 3?d and 7?d group was higher obviously than that of normal group,sham-operated and saline-control groups. That of 14?d group was approximate to normal group.Conclusion ET-A receptor may play an important role in pathogenesis of SAH-induced cerebral vessel spasm.