Expression of cytosolic phospholipase A2, 5-lipoxygenase and LTC4 synthetase mRNA in the peripheral polymorphonuclear leukocytes of patients with systemic lupus erythematosus / 中华风湿病学杂志

ABSTRACT

0.05, both). The mean levels of 5-LO and LTC4-S mRNA expression in active SLE group were significantly higher than those in normal controls respectively (P0.05). Conclusion The levels of 5-LO and LTC4-S mRNA expression in active SLE group increase markedly, which may be involved in the pathogenesis of SLE and provide a valuable scientific basis for the clinical use of specific 5-LO inhibitors and cysteinyl leukotrienes receptor antagonists.