Pharmacokinetic study of minister, adjuvant, and guide herbs in Mahuang Decoction to ephedrine in monarch herb in vivo / 中草药

ABSTRACT

Objective To develop a GC-MS method for the determination of ephedrine in human plasma and study the pharmacokinetic parameters of the ephedrine in different compatibility of the minister, adjuvant, and guide herbs to the monarch herb in Mahuang Decoction. Methods Orthogonal design was used to determine eight compatible groups from Mahuang Decoction (MHD). The healthy male volunteers were divided into groups in random, each group concluding eight men. After taking the medicine orally, venous blood would be taken out at different times. Determining ephedrine in plasma and plotting the concentration-time curve, the pharmacokinetic parameters of each compatible group were calculated by WinNonlin 4.0.1. The statistical analysis of the pharmacokinetic parameters were proceeded by SPSS 10.0. Results All concentration-time curves were adequately modeled by one compartment, first order absorption model, and no lag time. Some parameters of ephedrine showed significant variance (P