Effect of mobility training on astrocyte, synapse and motor skill in rats with acute cerebral infarction / 中华物理医学与康复杂志

ABSTRACT

Objective To investigate the change of and relationship between astrocytes and synapse structure in the region around the infarction area and the roles of the astrocytes on the recovery of motor skill in the experimental rats with acute cerebral infarction after mobility training. Methods A total of 120 rats were randomly divided into 4 groups a rehabilitation group, an inhibition group, a saline group and a control group. The motor skill of the rats was examined by beam walking test. The changes of astrocytes, synapses, the glial fibrillary acidic protein (GFAP), synaptophysin and growth associated protein 43(GAP-43) in the region around the infarction were observed using electron microscope and immunohistochemistry staining at 7,21 and 42 d after the model was made. Results It was noted that the recovery of motor skill was more significant in the rehabilitation group than that in the control and the inhibition groups (scored in beam walking test at 3.2?0.3 vs 1.8?0.5 and 1.6?0.9 at the third weekend; scored 5.8?0.9 vs 2.6?0.8 and 2.1?0.7scores at the sixth weekend. P