The experiment research of amino in neurotoxin from agkistrodon / 重庆医科大学学报

ABSTRACT

Objective:To modify amino in the neurotoxin,learn about modified neurotoxin′s activity.Methods:We made rat models that were suffered from spinal injury and had marked muscular hypertonia.We separated neurotoxin from agkistrodon in ZheJiang,modified amino in the neurotoxin by using acetic anhydride,then applied the modified neurotoxin to rats in order to know about its effects,and used the physiological recorder to authenticate its effects.Results:The modified neurotoxin was applied to the rats by injecting to the abdominal cavity.These rats 'muscular hypertonia was improved,and their survival time was much longer.Conclusion:Amino in the neurotoxin is an important radical.