Comparison of Pharmacological Action and Acute Toxicity Test Between Chuanxinlian Soft Capsules and Chuanxinlian Tablets / 广州中医药大学学报

ABSTRACT

[Objective] To compare the antipyretic and anti-inflammatory actions and acute toxicity between Chuanxinlian Soft Capsules (CSC) and Chuanxinlian Tablets. [Methods] Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide (LPS) and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti-inflammatory action oi CSC. Its acute toxicity in mice was also evaluated. [Results] High- and moderate-dose CSC reduced fever in rabbits induced by LPS (P 0.05). High-, moderate- and low-dose CSC has an inhibitory effect on acute inflammatory exudation (P