Effects of Mahuang Decoction in Different Combinations on Diaphoretic Function in Rats / 中药新药与临床药理

ABSTRACT

Objective To study the influence of Mahuang Decoction(MD)in different combinations on diaphoretic function in rats.Methods Vacuole incidence of axillary sweat gland was determined by observing the histolomorphological changes of vacuole to evaluate the diaphoretic function.The diaphoretic function was observed in 30 minutes after administration.Results The combination of Mahuang(Herba Ephedrae)and Guizhi(Ramulus Cinnamomi)had the strongest diaphoretic function in all of the different combinations.The diaphoretic function of the combinations including Mahuang(Herba Ephedrae)was stronger than those excluding Mahuang(Herba Ephedrae).The diaphoretic function of Mahuang(Herba Ephedrae)became stronger when used together with Guizhi(Ramulus Cinnamomi),remained the same when used together with Xingren(Semen Armeniacea Amarum),and became weaker when used together with Gancao(Radix Glycyrrhizac).Conclusion Mahuang(Herba Ephedrae),Guizhi(Ramulus Cinnamomi),Xingren(Semen Armeniacea Amarum),and Gancao(Radix Glycyrrhizac)play the roles of principle drug,assistant drug,adjuvant drug and conductantr drug respectively in Mahuang Decoction,which embodying the method of composing a prescription.