Relationship between the age of menarche,menopause and other factors and postmenopause osteoporosis / 中华妇产科杂志

ABSTRACT

Objective To evaluate the relationship between osteoporosis(OP) and the age of menarche and menopause,parity and lactation and bone mineral density(BMD).Methods BMD was measured in 1472 postmenopausal women by Norland XR-36 dual energy Xray absorptiometry(DXA) from May 1999 to April 2003 in our hospital.All data of BMD were compared and statistically analyzed between women with different age of menarche and menopause,parity and lactation period.The diagnostic criteria of osteoporosis was defined by a loss of BMD greater than 2.5 standard deviations below average peak BMD of young adult women.Results In all 1472 subjects,the incidence of osteoporsis is 58.5%(861/1472).There was significant increase in osteoporosis of lumbar spine in women with the age of menarche≥17(119 out of 336 cases were with osteoporosis in lumbar)compared with women with age of menarche≤13(75 out of 276 cases were with osteoporosis in lumbar).In women with menarche age of 11-13,14-16,17-19,lumbar vertebral(L_(2-4)) BMD values were(0.83?0.16),(0.82?0.16),(0.80?0.14) g/cm~2,respectively.There was significant increase in BMD of lumbar in the menarche age group of 11-13 compared with the age group of 17-19 in women within menopause 1-10 years(P